Intravenous thrombolysis in stroke patients of ≥80 versus <80 years of age—a systematic review across cohort studies
نویسندگان
چکیده
منابع مشابه
Intravenous thrombolysis in stroke patients of > or = 80 versus < 80 years of age--a systematic review across cohort studies.
OBJECTIVE elderly stroke patients were excluded or underrepresented in the randomised controlled trials of intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) applied within 3 h. Cohort studies comparing intravenous rtPA in stroke patients of >/=80 versus <80 years of age were limited by small sample sizes and yielded conflicting results. Thus, we performed a systemati...
متن کاملIntravenous thrombolysis in patients older than age 80 years.
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متن کاملIntravenous thrombolysis in acute ischaemic stroke: a systematic review and meta-analysis to aid decision making in patients over 80 years of age.
Introduction Patients ≥ 80 years of age are increasingly receiving intravenous thrombolysis for acute ischaemic stroke (AIS) despite lack of firm evidence. This systematic review assesses the safety and efficacy of intravenous thrombolysis with alteplase in ≥ 80 versus < 80 year old patients with AIS. Methods The existing literature was systematically analysed for outcome measures of mortality,...
متن کاملIntravenous Thrombolysis with Recombinant Tissue Plasminogen Activator for Ischemic Stroke Patients over 80 Years Old: The Fukuoka Stroke Registry
OBJECTIVES The benefit of intravenous recombinant tissue plasminogen activator (rt-PA) therapy for very old patients with acute ischemic stroke remains unclear. The aim of this study was to elucidate the efficacy and safety of intravenous rt-PA therapy for patients over 80 years old. METHODS Of 13,521 stroke patients registered in the Fukuoka Stroke Registry in Japan from June 1999 to Februar...
متن کاملOutcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (> or =80 years) stroke patients.
BACKGROUND AND PURPOSE Information on safety and efficacy of intravenous thrombolysis with tissue plasminogen activator (tPA) (IV-tPA) in very old acute ischemic stroke (AIS) patients is scarce. We studied outcome and severe hemorrhagic complications in patients aged 80 and older. METHODS We analyzed data of AIS patients, treated with IV-tPA, in 3 German stroke centers. Neurologic deficit on ...
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ژورنال
عنوان ژورنال: Age and Ageing
سال: 2006
ISSN: 1468-2834,0002-0729
DOI: 10.1093/ageing/afl104